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SB 218795
CAS No. 174635-53-1
SB 218795( —— )
Catalog No. M27703 CAS No. 174635-53-1
SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
|
| 10MG | 155 | Get Quote |
|
| 25MG | 312 | Get Quote |
|
| 50MG | 507 | Get Quote |
|
| 100MG | 714 | Get Quote |
|
| 500MG | 1503 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSB 218795
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NoteResearch use only, not for human use.
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Brief DescriptionSB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.
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DescriptionSB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.(In Vitro):SB 218795 (3-30 nM) antagonizes the contractile responses senktide-induced in a surmountable and concentration-dependent manner.(In Vivo):In rabbits, SB?218795 (0.25-1?mg/kg; i.v.) inhibits NK3 receptor-mediated pupillary constriction by maximum inhibition of 78%.
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In VitroSB 218795 (3-30 nM) antagonizes the contractile responses induced by the NK3 receptor agonist senktide in a surmountable and concentration-dependent manner.SB 218795 (0.3-3?μM) does not affect the contractile responses of the NK3 receptor agonist [MePhe7]-NKB in the rabbit iris sphincter muscle.
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In VivoSB?218795 (0.25-1?mg/kg; i.v.) inhibits Senktide-induced miosis in rabbits by the maximum inhibition of 78%.
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Synonyms——
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PathwayGPCR/G Protein
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TargetNeurokinin Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number174635-53-1
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Formula Weight396.446
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Molecular FormulaC25H20N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (630.61 mM)
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SMILESCOC(=O)[C@@H](NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Carnat A1, et al. Luteolin 7-diglucuronide, the major flavonoid compound from Aloysia triphylla and Verbena officinalis.Planta Med. 1995 Oct;61(5):490.
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